Will Brad Pitt or Leonardo DiCaprio replace Johnny Depp for the leading role of the movie The Tourist? The intense sex scene between Angelina Jolie and Depp angered Vanessa Paradis who called her 'husband' home.
Depps defines marriage as 2 people loving each other and being together, he has been dating Paradis for 12 years and they have 2 children together.

Johnny Depp & Vanessa Paradis during the 9th Annual Critics Choice Awards, 2004
Jolie on the other hand has a history of breaking marriages:
Jennifer Aniston broke up with Brad Pitt after his love scene with Jolie in Mr. & Mrs. Smith... so did Billy Bob Thornton and Laura Dern after Thornton' scene with Jolie in the comedy/drama Pushing Tin